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CT 53518 - MLN 518 -Tandutinib

CAS 387867-13-2

C31H42N6O4 MW 562.70

Purity: 99%

Ordering Information:

Cat. No. Axon 1415        Prime Source

Qty1: 5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg @ €140  $182

Qty2: 25 mg (research sample) / €285  $371

Promotion: 2 x 25 mg @ €420  $546

Qty3: on request

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Biological Activity:   An oral tyrosine kinase inhibitor (TKI), targeting FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGFR, thereby inhibiting cellular proliferation and inducing apoptosis.   References: online 1, 2, 3, 4, 5   L Kelly et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell , 2003, 1(5), 421 - 432. [online abstract]   IJ Griswold et al. Effects of MLN518, a dual FLT3 and KIT inhibitor, on normal and malignant hematopoiesis. Blood 2004, 104(9), 2912-8. [online abstract]     Chemical Name: 1-piperazinecarboxamide, 4-[6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-

CT 53518 - MLN 518 - Tandutinib | FLT3 inhibitor | Axon Medchem | Axon 1415 | CT53518 - MLN0518 - MLN518

Axon Ligands ^TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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