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AG 013736 - Axitinib

CAS 319460-85-0

C22H18N4OS MW 386.47

Purity: 99%

Soluble in DMSO to 100 mM

Ordering Information:

Cat. No. Axon 1414        

Qty1: 5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg  / €140  $182 

Qty2: 25 mg (research sample) / €285  $371

Promotion: 2 x 25 mg  / €420  $546 

Qty3: on request contract research synthesis

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Biological Activity:   A tyrosine kinase inhibitor (TKI), targeting VEGFR/PDGFR/c-KIT; orally bioavailable drug exerting an anti-angiogenic effect.   References: online 1, 2, 3, 4   LG Wilmes et al. AG-013736, a novel inhibitor of VEGF receptor tyrosine kinases, inhibits breast cancer growth and decreases vascular permeability as detected by dynamic contrast-enhanced magnetic resonance imaging. Magn. Reson. Imaging 2007, 25(3), 319-327.   HS Rugo et al. Phase I trial of the oral antiangiogenesis agent AG-013736 in patients with advanced solid tumors: pharmacokinetic and clinical results. J. Clin. Oncol. 2005, 23(24), 5474-5483.     Chemical Name: N-Methyl-2-[[3-[(E)-2-pyridin-2-ylethenyl]-1H-indazol-6-yl]sulfanyl]benzamide

AG 013736 - Axitinib | VEGFR inhibitor | Axon Medchem | Axon 1414 | AG013736

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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