Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

Vandetanib - ZD 6474

CAS 443913-73-3

C22H24BrFN4O2  MW 475.35

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1411          Prime Source

Qty1: 5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg @ €140  $182

Qty2: 25 mg (research sample) / €285  $371

Promotion: 2 x 25 mg @ €380  $494

Qty3: on request

Send enquiry to:  order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

Biological Activity:   A orally bioavailable tyrosine kinase inhibitor (TKI), targeting VEGFR and EGFR; a potential medication for non-small-cell lung cancer.   References: online 1, 2   RS Herbst et al. Vandetanib (ZD6474): an orally available receptor tyrosine kinase inhibitor that selectively targets pathways critical for tumor growth and angiogenesis. Expert Opin. Investig. Drugs. 2007, 16, 239-249.   SR Wedge et al. ZD6474 Inhibits Vascular Endothelial Growth Factor Signaling, Angiogenesis, and Tumor Growth following Oral Administration. Cancer Res. 2002, 62, 4645-4655.         Chemical Name: N-(4-bromo-2-fluorophenyl)-6-methoxy-7-[(1-methylpiperidin-4-yl)methoxy]quinazolin-4-amine

Vandetanib - ZD 6474 | VEGFR inhibitor | Axon Medchem | Axon 1411 | ZD6474 - AZD 6474

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com © 2012