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PD 0325901

CAS 391210-10-9

C16H14F3IN2O4  MW 482.19

Purity: 99% (optically pure)

Soluble in DMSO

(Second Generation MEK inhibitor)

Ordering Information:

Cat. No. Axon 1408    Prime Source 

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty3: 25 mg (research sample) / €505  $657

Promotion: 2 x 25 mg @ €700  $910

Qty4: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

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Biological Activity:   Potent, highly specific non-ATP-competitive inhibitor of MEK (aka MKK) 1/2; a derivative of CI-1040 (Axon 1368) to improve bioavailability; clinical candidate and highly recommended tool to inhibit MKK1 or MKK1 plus MKK5 in cells.   References:   J Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007, 408(Pt 3), 297–315. [online]   QL Ying et al. The ground state of embryonic stem cell self-renewal. Nature, 2008, 453, 519-523. [online]   SD Barrett et al. The discovery of the benzhydroxamine MEK inhibitors CI-1040 and PD 0325901. Bioorg. Med. Chem. Lett. 2008, 18, 6501-6504.   C Frémin and S Meloche. From basic research to clinical development of MEK1/2 inhibitors for cancer therapy. J. Hematol. Oncol. 2010, 3, 8. [online]      Chemical Name: N-[((R)-2,3-Dihydroxypropyl)oxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide

PD 0325901 | MEK 1/2 inhibitor | Axon Medchem | Axon 1408 | PD0325901

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Prime Source Information:

PD 0325901 from Axon Medchem has been procured by many labs as drug standard for generating reliable and reproducible biological data, evidenced by many recent publicaiotns.