CP 101606 | NMDA antagonist | Axon Ligands | Axon Medchem | Traxoprodil mesylate

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CP 101606 mesylate -

Traxoprodil mesylate

CAS 189894-57-3 (MsOH)

134234-12-1 (free base)

C20H25NO3.CH4O3S

Purity: 99% (optically pure)

Soluble in water and DMSO

Ordering Information:

Cat. No. Axon 1406 2012 Promotion

Qty1: 5 mg (research sample) / 105 $137

Promotion: 2 x 5 mg @ 160 $208

Qty2: 25 mg (research sample) / 405 $527

Promotion: 2 x 25 mg @ 600 $780

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent and NR2B selective antagonist of NMDA glutamate receptors; the mesylate salt is the optimal water-soluble drug form.

References: online 1, 2, 3, 4

K Taniguchi etal. Antinociceptive activity of CP-101,606, an NMDA receptor NR2B subunit antagonist. Br. J. Pharmacol. 1997, 122, 809812.

FS. Menniti etal. CP-101,606: An NR2B-Selective NMDA Receptor Antagonist. CNS Drug Rev. 1998, 4(4), 307-322.

L Yurkewicz etal. The effect of the selective NMDA receptor antagonist traxoprodil in the treatment of traumatic brain injury. J. Neurotrauma. 2005, 22(12), 1428-43.

JG Nutt etal. Effects of a NR2B selective NMDA glutamate antagonist, CP-101,606, on dyskinesia and parkinsonist. Mov. Disord. 2008, 23(13), 1860-1866.

Chemical Name:1-[(1S,2S)-2-Hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]-4-phenylpiperidin-4-ol mesylate

CP 101606 | NMDA antagonist | Axon Medchem | Traxoprodil mesylate | Axon 1406 | CP101606 - CP-101,606 supplier

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.