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LY 333531 mesylate -Ruboxistaurin

CAS 192050-59-2

169939-94-0 (free base)

C28H28N4O3.CH4O3S  MW 564.65

Purity: 99% (optically pure)

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1401     Prime Source

 

Qty1: 1 mg (research sample) / €99  $129

Qty2: 2 mg (research sample) / inquire

Qty3: 5 mg (research sample) / inquire

 

Qty4: on request contract research synthesis

 

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Biological Activity:

 

Orally active protein kinase C beta (PKCβ) specific inhibitor; the optimal salt form and five times more water-soluble than its hydrochloride salt.

 

References:

 

Ruboxistaurin: LY 333531. Drug R. D. 2007, 8(3), 193-199. [online]

 

LY-333531 mesylate hydrate. Drugs Fut. 2000, 25(10), 1017. [online]

 

GL Engel et al. Salt form selection and characterization of LY333531 mesylate monohydrate. Int. J. Pharmaceutics 2000, 198(2), 239-247. [online]

 

MR Jirousek et al. (S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacy clohexadecene-1,3(2H)-dione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta. J. Med. Chem. 1996, 39, 2664. [online]

 

Y Wu et al. Protein kinase C beta inhibitor LY333531 attenuates intercellular adhesion molecule-1 and monocyte chemotactic protein-1 expression in the kidney in diabetic rats. J. Pharmacol. Sci. 2006, 101(4), 335-343. [online] 

 

S Tang et al. Protein kinase C isozymes and their selectivity towards ruboxistaurin. Proteins. 2008, 72(1), 447-60. [online]

 

 

Chemical Name: 9H,18H-5,21:12,17-Dimethenodibenzo[e,k]pyrrolo[3.4-h][1,4,13]oxadiazacyclohexadecine-18,20(19H)-dione, 9-[(dimethylamino)methyl]-6,7,10,11-tetrahydro-, (9S)-, methanesulfonate (1:1)

 

LY 333531 | PKCβ Inhibitor | Axon Medchem | Axon 1401 | LY333531 mesylate - Ruboxistaurin

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Ligands In The Field:

 

AEB 071 | PKC inhibitor

LY 317615 | PKCβ inhibitor

LY 333531 | PKCβ inhibitor

 

CID 755673 | PKD inhibitor

 

 

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