CHIR99021 - CT99021 | Laduviglusib

Based on 18711 reference(s) in Google Scholar 100 100 18711

Axon 1386

CAS [252917-06-9]

MF C22H18Cl2N8
MW 465.34

Purity: 99%
Soluble in 0.1N HCl(aq) and DMSO

CHIR99021

Description

Very potent and specific glycogen synthase kinase GSK-3 inhibitor; highly recommended tool. * CHIR99021 and PD0325901 (Axon 1408) are often used together as 2i in stem cell research (Axon 2128).

CHIR99021 is also available as the water soluble HCl salt (Axon 2435)

*Promotion: CHIR99021 is also part of Inhibitor Set(s):

Axon 2128	Axon 2129	Axon 2130	Axon 5005
Axon 5006	Axon 5007	Axon 5009	Axon 5010

Prime Source Information:

CHIR99021 from Axon Medchem has been procured by many labs as a drug standard for generating reliable and reproducible biological data, evidenced by many recent publications (>900 citations). It is pure not only chemically but also biologically.

C Tong et al. Generating gene knockout rats by homologous recombination in embryonic stem cells. Nature Protocols 2011, 6, 827–844.

M Kawamata and T Ochiya. Generation of genetically modified rats from embryonic stem cells. PNAS 2010, 107(32), 14223-14228.

MY Chang et al. Direct Reprogramming of Rat Neural Precursor Cells and Fibroblasts into Pluripotent Stem Cells. PLoS One. 2010, 5(3), e9838.

IM Aparicio et al. Identification and regulation of glycogen synthase kinase-3 during bovine embryo development. Reproduction 2010, 140, 83-92.

B Zimmer et al. Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing. Cell Death and Differentiation. 2011, 18, 383–395.

Q.L.Ying et al. The ground state of embryonic stem cell self-renewal. Nature. 2008, 453, 519-523.

J. Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem. J. 2007, 408, 297-315.

D.B. Ring et al. Selective glycogen synthase kinase 3 inhibitors potentiate insulin activation of glucose transport and utilization in vitro and in vivo. Diabetes. 2003, 52, 588-595.

A.S. Wagman et al. Discovery and development of GSK3 inhibitors for the treatment of type 2 diabetes. Curr. Pharm. Des. 2004, 10, 1105-1137.

List of publications using CHIR99021 (Axon 1386) purchased from Axon Medchem

Cell Signaling & Oncology CNS Diabetes & Metabolism Immunology Pain & Inflammation Stem Cell GSK-3 Wnt-β-Catenin PI3K-Akt-mTOR EC 2.7.11.26

GSK-3 inhibitor

Chemical name

6-{2-[4-(2,4-Dichloro-phenyl)-5-(5-methyl-1H-imidazol-2-yl)-pyrimidin-2-ylamino]-ethylamino}-nicotinonitrile

Parent CAS No.

[252917-06-9]

Order

Size	Unit Price	Stock
2 mg	€60.00	In Stock
5 mg	€80.00	In Stock
25 mg	€280.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€130.00	In Stock
2 x 25 mg	€460.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description
1126	CHIR98014	GSK-3 inhibitor	€99.00
1303	SB 216763	GSK-3 inhibitor	€85.00
1527	XAV939	Tankyrase (TNKS) inhibitor	€80.00
1562	TWS 119	GSK-3β inhibitor	€70.00
1693	BIO	GSK-3 inhibitor	€90.00
1766	ICG 001	Specific inhibitor of Wnt/β-catenin signaling pathway	€115.00
1909	A 1070722	Selective inhibitor of GSK-3	€95.00
1922	JW 55	Inhibitor of tankyrase (TNKS 1 and 2)	€95.00
2010	TDZD 8	Selective and non-ATP-competitive inhibitor of GSK-3β	€90.00
2036	KY 02111	Canonical Wnt signaling pathway inhibitor	€80.00
2084	SKL 2001	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2120	Wnt agonist 1	Wnt/β-catenin signaling pathway agonist or activator	€90.00
2133	iCRT5	β-Catenin-responsive transcription (CRT) inhibitor	€80.00
2167	AR-A 014418	ATP-competitive GSK-3 inhibitor	€85.00
2171	AZD1080	Selective inhibitor of GSK-3α and GSK-3β	€90.00
2194	AZD2858 hydrochloride	Potent and highly selective Glycogen Synthase Kinase-3β inhibitor	€95.00
2287	Wnt-C59	Highly potent porcupine (Porcn) inhibitor	€75.00
2128	Stem Cell 2i inhibitor Set	Set of MEK inhibitor PD0325901 (Axon 1408) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€90.00
2129	Stem Cell 3i inhibitor Set	Set of FGFR inhibitor SU5402 (Axon 1667), MEK inhibitor PD184352 (Axon 1368) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€130.00
2130	Stem Cell Alternative 2i inhibitor Set	Set of SRC inhibitor CGP77675 (Axon 2097) and GSK-3 inhibitor CHIR99021 (Axon 1386)	€110.00
2435	CHIR99021 dihydrochloride	GSK-3 inhibitor	€60.00
2135	iCRT14	Small-molecule inhibitor of the Wnt/wingless signaling pathway; CRT inhibitor	€135.00
2466	Gö 6983	Broad spectrum PKC inhibitor lacking inhibitory effect for PKCμ	€90.00
2511	IM 12	GSK-3β inhibitor attenuating neuronal differentiation of human NPCs	€95.00
2651	OAC2	Oct4 and Nanog activating compound that enhances reprogramming efficiency	€60.00
2656	CRT0066854	Selective ATP-competitive inhibitor of the atypical PKC isoenzymes	€135.00
3153	BRD5648	Negative control compound of BRD0705 as a GSK3α inhibitor	€210.00
3154	rac-BRD0705	GSK3α inhibitor	€140.00
2931	BRD0705	First-in-class, paralog selective GSK3α inhibitor	€210.00
3579	Tideglusib	GSK-3 inhibitor	€60.00
3715	E-7386	CBP/beta-catenin modulator	Inquire
3748	C-82	Specific inhibitor of Wnt/β-catenin signaling pathway	€110.00
3749	PRI-724	Specific inhibitor of Wnt/β-catenin signaling pathway	€190.00
3771	AZD2858	Potent and highly selective Glycogen Synthase Kinase-3β inhibitor	€95.00
3936	Bisindolylmaleimide I	Potent and selective PKC inhibitor	€120.00

Customer Support

Customer Services

About Axon Medchem

Contact Us

CHIR99021 - CT99021 | Laduviglusib

Description

Chemical name

Parent CAS No.

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Customer Support

Customer Services

About Axon Medchem

Contact Us

CHIR99021 - CT99021 | Laduviglusib

Description

Chemical name

Parent CAS No.

Related Products

Customer Support

About Axon Medchem

Download Product Catalog

Follow Us

Send us a message

Contact Us