SB 742457 | 5-HT6 antagonist | Axon Ligands | Axon Medchem

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SB 742457

GSK 742457

CAS 607742-69-8, 607742-55-2 (HCl)

C19H19N3O2S.HCl MW 389.90

Purity: 99%

Soluble in DMSO to 100 mM

Soluble in water to 10 mM

Ordering Information:

Cat. No. Axon 1382 Prime Source

Qty1: 5 mg (research sample) / 105 $137

Promotion: 2 x 5 mg @ 160 $208

Qty2: 25 mg (research sample) / 380 $494

Promotion: 2 x 25 mg @ 560 $728

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Selective 5-HT6 antagonist; a potential agent added to stablize donepezil (Axon 1438) treatment in subjects with mild-to-moderate Alzheimer's disease.

References: online 1, 2, 3, 4

N Idris et al. Sertindole improves sub-chronic PCP-induced reversal learning and episodic memory deficits in rodents: involvement of 5-HT(6) and 5-HT (2A) receptor mechanisms. Psychopharmacology 2010, 208 (1), 2336. [online]

G Maher-Edwards et al. Double-Blind, Controlled Phase II Study of a 5-HT6 Receptor Antagonist, SB-742457, in Alzheimer's Disease. Curr. Alzheimer Res. 2009, 7(5), 374-385. [online]

G Rossé G and H Schaffhauser. 5-HT(6) Receptor Antagonists as Potential Therapeutics for Cognitive Impairment. Curr. Top. Med. Chem. 2010, 10(2), 207-221. [online]

N Upton et al. 5-HT6 receptor antagonists as novel cognitive enhancing agents for Alzheimer's disease. Neurotherapeutics 2008, 5(3), 458469. [online]

Chemical Name: 3-Benzenesulfonyl-8-piperazin-1-yl-quinoline trihydrochloride

SB 742457 | 5-HT6 antagonist | Axon Medchem | Axon 1382 | SB742457 - GSK743457 - GSK 742457

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com Š 2011

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