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PF 477736

CAS 952021-60-2

C22H25N7O2  MW 419.21

Purity: >98% (optically pure)

Ordering Information:

Cat. No. Axon 1379    Stock Resumed

Qty1: 2 mg (research sample) / €95  $124

Qty2: 5 mg (research sample) / €145  $189

Qty3: on request contract research synthesis

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or by fax to: +31-50-3600390.

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Biological Activity:   Chk1 inhibitor with Ki values of 0.49 and 47 nM for Chk1 and Chk2 respectively. A proprietary compound targeting cell cycle checkpoint kinase 1 (chk1) with potential chemopotentiation activity.     References: online 1, 2, 3   JW Janetka et al, Inhibitors of Checkpoint Kinases: From discovery to the clinic. Curr. Opin. Drug Discov. & Devel. 2007, 10(4), 473-486.   S. Ashwell and S Zabludoff. DNA Damage Detection and Repair Pathways Recent Advances with Inhibitors of Checkpoint Kinases in Cancer Therapy. Clin. Cancer Res. 2008, 14(13), 4033-4037.     Chemical Name: (R)-2-Amino-2-cyclohexyl-N-[2-(1-methyl-1H-pyrazol-4-yl)-6-oxo-5,6-dihydro-1H-[1,2]diazepino[4,5,6-cd]indol-8-yl]-acetamide dihydrochloride

PF 477736 | CHK1 inhibitor | Axon Medchem | Axon 1379 | PF477736 - PF-00477736

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands in The Field:

AZD 7762 | CHK inhibitor

CHIR 124 | CHK1 inhibitor

PF 477736 | CHK1 inhibitor

MK 1775 | Wee1 inhibitor

MJ O'Connell et al. EMBO J. 1997, 16, 545 - 554