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AG 490 - Tyrphostin AG-490

Tyrphostin B42

CAS 133550-30-8

C17H14N2O3  MW 294.31

Purity: 99%

Ordering Information:

Cat. No. Axon 1378

Qty1: 10 mg / €65  $85

Qty2: 50 mg / €165  $215

Qty3: on request

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Biological Activity:   Janus Kinase 2 (JAK2) inhibitor   References: online 1, 2   N Miyamoto et al. The JAK2 inhibitor AG490 predominantly abrogates the growth of human B-precursor leukemic cells with 11q23 translocation or Philadelphia chromosome. Leukemia 2001, 15, 1758-1768.   O Sareila et al. JAK Inhibitors AG-490 and WHI-P154 Decrease IFN-γ-Induced iNOS Expression and NO Production in Macrophages. Mediators Inflamm. 2006, 2006(2), 16161.   N Meydan, et al. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 1996, 379, 645-648.     Chemical Name: (E)-2-Cyano-3-(3,4-dihydrophenyl)-N-(phenylmethyl)-2-propenamide

AG 490 | JAK2 inhibitor | Axon Medchem | Axon 1378 | Tyrphostin AG-490

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