GYKI 53655 | AMPA antagonist | Axon Ligands | Axon Medchem | Axon 1374

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GYKI 53655

LY 300168

CAS 143692-18-6

C19H20N4O3 MW 352.40

Purity: >99%

Ordering Information:

Cat. No. Axon 1374 Prime Source

Qty1: 2 mg (research sample) / 85 $111

Qty2: 5 mg (research sample) / 125 $163

Promotion: 2 x 5 mg @ 180 $234

Qty3: 25 mg (research sample) / 430 $559

Promotion: 2 x 25 mg @ 660 $858

Qty4: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Selective AMPA receptor antagonist; a more useful tool than NBQX for the study of AMPA receptor-mediated processes in vivo.

References: online 1, 2, 3, 4

BA Chizh et al. A comparison of intravenous NBQX and GYKI 53655 as AMPA antagonists in the rat spinal cord. Br. J. Pharmacol. 1994, 112(3), 843-6.

AD Kovács and G Szabó. GYKI 53655, a 2,3-benzodiazepine, non-competitively protects cultured neurones against AMPA toxicity. Eur. J. Pharmacol. 1997, 331(1), 93-96.

Szabados et al. Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405 and GYKI 53655. Brain. Res. Bull. 2001, 55 387.

Chemical Name: 1-(4-aminophenyl)-3-methylcarbamyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine

GYKI 53655 | AMPA antagonist | Axon Medchem | Axon 1374 | LY 300168 - GYKI53655 - LY300168