|
Biological Activity:
Potent inhibitor of poly(ADP-ribose) polymerase (PARP); reported to have neuroprotective effects.
References: online 1, 2, 3
R Kaundal et al. Neuroprotective effects of NU1025, a PARP inhibitor in cerebral ischemia are mediated through reduction in NAD depletion and DNA fragmentation. Life Sciences 2006, 79(24), 2293-302.
KJ Bowman et al. Potentiation of anti-cancer agent cytotoxicity by the potent poly(ADP-ribose) polymerase inhibitors NU1025 and NU1064. Br. J. Cancer. 1998, 78 1269.
CA Delaney et al. Potentiation of temozolomide and topotecan growth inhibition and cytotoxicity by novel poly(adenosine diphosphoribose) polymerase inhibitors in a panel of human tumor cell lines. Clin. Cancer Res. 2000, 6, 2860.
Chemical Name: 8-Hydroxy-2-methyl-3H-quinazolin-4-one
| 
