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PD 184352 - CI-1040

CAS 212631-79-3

C17H14ClF2IN2O2  MW 478.67

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1368    Prime Source

Qty1: 5 mg (research sample) / €125  $163

Promotion: 2 x 5 mg @ €160  $208

Qty2: 25 mg (research sample) / €375  $488

Promotion: 2 x 25 mg @ €560  $728

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

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Biological Activity:   Potent, selective and non-competitive inhibitor of MEK 1 (also called MKK 1) and its activation; highly recommended tool to inhibit MKK1 or MKK1 plus MKK5.   References: online 1, 2, 3   RR Mattingly et al. The MEK inhibitor PD184352/CI-1040 selectively induces apoptosis in malignant schwannoma cell lines. J. Pharmacol. Exp. Ther. 2006, 316, 456-465.   D Liu et al. Inhibitory Effects of the Mitogen-Activated Protein Kinase Kinase Inhibitor CI-1040 on the Proliferation and Tumor Growth of Thyroid Cancer Cells with BRAF or RAS Mutations. J. Clin. Endocrinol. & Meta. 2007, 92 (12), 4686-4695.   QL Ying et al. The ground state of embryonic stem cell self-renewal. Nature, 2008, 453, 519-523. [online]     Chemical Name: 2-(2-Chloro-4-iodo-phenylamino)-N-cyclopropylmethoxy-3,4-difluoro-benzamide

PD 184352 - CI-1040 | MEK 1 inhibitor | Axon Medchem | Axon 1368 | PD184352 - CI1040

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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