KU 55933 | ATM Inhibitor | Axon Medchem | Axon 1367

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Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

KU 55933

CAS 587871-26-9

C21H17NO3S2 MW 395.49

Purity: 99%

Soluble in DMSO and EtOH

Ordering Information:

Cat. No. Axon 1367 Prime Source

Qty1: 10 mg (research sample) / 125 $163

Qty2: 50 mg (research sample) / 375 $488

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent, ATP-competitive and selective ATM inhibitor (Ki = 2.2 nM, IC50 = 13 nM)

References:

I Hickson et al. Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM. Cancer Res. 2004, 64, 9152. [online]

A Lau et al. Suppression of HIV-1 infection by a small molecule inhibitor of the ATM kinase. Nat. Cell Biol. 2005, 7, 493-500. [online]

Y Li and DQ Yang. The ATM Inhibitor KU-55933 Suppresses Cell Proliferation and Induces Apoptosis by Blocking Akt In Cancer Cells with Overactivated Akt.
Mol. Cancer Ther. 2010, 9, 113. [online]

Chemical Name: 2-Morpholin-4-yl-6-thianthren-1-yl-pyran-4-one

KU 55933 | ATM Inhibitor | Axon Medchem | Axon 1367 | KU55933