PIK 90

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1362

CAS [677338-12-4]

MF C18H17N5O3
MW 351.36

Purity: 99%
Moderately soluble in DMSO with 0.1N HCl(aq)

PIK 90

Description

Potent and cell permeable PI3K inhibitor, with IC50 values (nM) of 11, 350, 18, and 58 for p110 α, β, γ and δ isoforms, low mTOR activity.

JS Chen et al. Characterization of structurally distinct, isoform-selective phosphoinositide 3′-kinase inhibitors in combination with radiation in the treatment of glioblastoma. Mol. Cancer Ther. 2008, 7, 841-850.

ZA Knight et al. A Pharmacological Map of the PI3-K Family Defines a Role for p110α in Insulin Signaling. Cell 2006, 125, 733–747.

C Chaussade et al. Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling. Biochem J. 2007, 404(3), 449–458.

S Kim et al. Insulin-like growth factor-1 regulates platelet activation through PI3-Kα isoform. Blood, 2007, 110(13), 4206-4213.

List of publications using PIK 90 (Axon 1362) purchased from Axon Medchem

PI3K inhibitor (p110-α specific)

Chemical name

N-(7,8-Dimethoxy-2,3-dihydro-imidazo[1,2-c]quinazolin-5-yl)-nicotinamide

Parent CAS No.

[677338-12-4]

Order

Size	Unit Price	Stock
5 mg	€85.00	In Stock
25 mg	€285.00	In Stock

Special Offers

Size	Unit Price	Stock
2 x 5 mg	€130.00	In Stock
2 x 25 mg	€440.00	In Stock

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PIK 90

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PIK 90

Description

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