BIRB 796 - Doramapimod | p38 MAPK inhibitor | Axon Ligands | Axon Medchem

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BIRB 796 - Doramapimod

CAS 285983-48-4

C31H37N5O3 MW 527.67

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1358 Prime Source

Qty1: 5 mg (research sample) / 100 $130

Qty2: 10 mg (research sample) / 145 $189

Promotion: 2 x 10 mg @ 220 $286

Qty3: 50 mg (research sample) / 475 $618

Promotion: 2 x 50 mg @ 720 $936

Qty4: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Small molecule inhibitor of p38 mitrogen-activated protein (MAP) kinase (MAPK); more potent than SB 203580 on p38α and p38β MAPKs; potential agent for the treatment of inflammatory diseases.

References:

C Pargellis et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site. Nat. Struct. Biol. 2002, 9, 268-272.

Y Kuma et al. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J. Boil. Chem. 2005, 280, 19472-19479.

J Bain et al. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007, 408, 297315. [online]

Chemical Name: 1-(5-tert-Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-[4-(2-morpholin-4-yl-ethoxy)-naphthalen-1-yl]-urea

BIRB 796 - Doramapimod | p38 MAPK inhibitor | Axon Medchem | Axon 1358 | BIRB 0796 - BIRB796