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SD 169

CAS 1670-87-7

C9H8N2O  MW 160.17

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1357

Qty1: 5 mg / €65  $85

Promotion: 10 mg / €95  $124

Qty2: 25 mg / €195  $254

Promotion: 50 mg / €295  $384

Qty3: on request

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Biological Activity:   ATP competitive, orally active inhibitor of p38α MAP kinase (IC50 = 3.2 nM); being 38 fold selective vs against p38β MAP kinase (IC50 = 122 nM) and no inhibitory activity against a panel of other kinases including p38γ MAP kinase, ERK2, JNK-1 and MAPKAPK-2.   References: online 1, 2   S Medicherla et al. Preventive and Therapeutic Potential of p38α Selective MAPK Inhibitor in NOD Mice with Type 1 Diabetes. J. Pharmacol. Exp. Ther. 2006, 318, 99-107.   Robert R. Myers et al. Inhibition of p38 MAP kinase activity enhances axonal regeneration. Exp. Neurol. 2003, 184(2), 606-614.     Chemical Name: indole-5-carboxamide

SD 169 | p38α MAPK inhibitor | Axon Medchem | Axon 1357 | SD169

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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