RO 28-1675 | Glucokinase activator | Axon Ligands

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Ro 28-1675

R-enantiomer of Ro 28-0450

CAS 300353-13-3

C18H22N2O3S2 MW 378.52

Purity: 99%, >99%ee

Ordering Information:

Cat. No. Axon 1356 Exclusive & Limited Stock

Qty1: 2 mg (research sample) / 125 $163

Qty2: 5 mg (research sample) / 185 $241

Qty3: 25 mg (research sample) / 750 $975

Qty3: on request contract research synthesis

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Glucokinase GK activator; more active R-enantiomer of Ro-28-0450 (Axon 1134) in comparison with S-enantiomer, Ro 28-1674 (Axon 1355).

References: online 1, 2

J Grimsby et al. Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy. Science Signaling 2003, 301(5631), 370-373.

T Kietzmann and GK Ganjam. Glucokinase: old enzyme, new target. Exp. Opin. Ther. Patents. 2005, 15(6), 705-713.

Chemical Name: (R)-3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

RO 28-1675 | Glucokinase activator | Axon Medchem | Axon 1356 | RO281675 - Ro28-1675 - Ro 0281675 - Ro 0281675

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

axonmedchem.com Š 2011

In the Spotlight

Ro 28-0450 was found as a highly effective GK activator in 2001. Later Roche identified its R-enantiomer (Ro 28-1675) as more active. Recent R&D highlighted on the following small molecule glucokinase activators: e.g.

Ro 28-1675

GKA1

GKA2

Thiophene22

Banyu compound

LY 2121260

PSN-GK1 - PSN-105 - PSN-010

and some "UREAs"

....

Click To See Signal Transduction Modulators At Axon Collection