Fenobam | mGluR5 antagonist | Axon Medchem

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Fenobam

McN 3377-98 - NPL 2009

CAS 57653-26-6

C11H11ClN4O2 MW 266.69

Purity: >99%

Ordering Information:

Cat. No. Axon 1345

Qty1: 10 mg / 66 $86

Promotion: 2 x 10 mg @ 100 $130

Qty2: 50 mg / 266 $346

Promotion: 2 x 50 mg @ 360 $468

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent and selective antagonist for metabotropic glutamate receptor subtype 5 (mGluR5)

References:

CTH Friedmann et al: Phase II double-blind controlled study of a new anxiolytic, fenobam (McN-3377) vs placebo. Curr. Ther. Res. 1980, 27, 144-151.

Porter et al. Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. J. Pharmacol. Exp. Ther. 2005, 315 711.

Chemical Name: 1-(3-Chloro-phenyl)-3-(1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl)-urea

Fenobam | mGluR5 antagonist | Axon Medchem | Axon 1345

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