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(S)-WAY 100135 dihydrochloride     CAS 149007-54-5 133025-23-7 (free base) C24H33N3O2.2HCl  MW 468.47 Purity: 99%, 99%ee

Ordering Information:   Cat. No. Axon 1341   Prime Source   Qty1: 5 mg / €95  $124   Qty2: 25 mg / €335  $436   Qty3: on request   Send enquiry to: order@axonmedchem.com or by fax to: +31-50-3600390.   Contact us for payment and tech support.

Biological Activity:   Highly selective serotonin 5-HT1A antagonist; S-enantiomer of WAY-100135 (Axon 1360).   * Its opposite enantiomer, (R)-WAY100135 (Axon 1359) is also available.   References: online 1, 2, 3   K Wdzony et al. WAY 100135, an Antagonist of 5-HT1A Serotonin Receptors, Attenuates Psychotomimetic Effects of MK-801. Neuropsychopharmacology 2000, 23, 547-559.   KF Rhodes et al. The antagonist actions of WAY 100135 and its enantiomers on 5-HT1A receptor-mediated hyperpolarization of the rat isolated superior cervical ganglion. Naunyn-Schmiedeberg's Arch. Pharmacol. 1993, 348(3), 225-227.   NA Escandon et al. Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. J. Pharmacol. Exp. Ther. 1994, 268, 441-447.     Chemical Name: (S)-N-tert-Butyl-3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-2-phenyl-propionamide dihydrochloride   (S)-WAY-100135 | 5-HT1A antagonist | Axon Medchem | Axon 1341 | (S) WAY100135   axonmedchem.com © 2011

Axon 5-HT1A Ligands: e.g. 8-OH-DPAT | 5-HT1A agonist (+)-8-OH-DPAT | 5-HT1A agonist (-)-NPPCC | 5-HT1A agonist S 14506 | 5-HT1A agonist Desmethyl S14506 U 92016A | 5-HT1A agonist LY 426965 | 5-HT1A antagonist p-MPPF | 5-HT1A antagonist p-MPPI | 5-HT1A antagonist WAY 100135 | 5-HT1A antagonist (S)-WAY100135 | 5-HT1A antag. WAY 100635 | 5-HT1A antagonist DWAY | 5-HT1A antagonist FWAY | 5-HT1A antagonist   Axon 5-HT1B/1D Ligands: e.g. CGS 12066B | 5-HT1B agonist  Sumatriptan | 5-HT1B/1D agonist GR 127935 | 5-HT1B/1D antagonist GMC 2-29 | 5-HT1B/1D antagonist GMC 3-15 | 5-HT1B/1D antagonist GMC 15-27 | 5-HT1B/1D antag. SB 216641 | 5-HT1B antagonist LY 393558 | SRI, 5-HT1B/1D antag   Axon 5-HT1F Ligands: LY 334370 | 5-HT1F agonist