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Biological Activity:
Blocker of the slow delayed rectifier K+ current via KCNQ1 channels
References: online ref 1
C Lengyel et al. Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. Br. J. Pharmacol. 2001, 132, 101-110.
G Seebohm et al. A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br. J. Pharmacol. 2001, 134, 1647-1654.
Chemical name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
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