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Chromanol 293B

 

 

CAS 163163-23-3

C15H20N2O4S  MW 324.40

Purity: 99%

 

 

 

 

Ordering Information:

 

Cat. No.: Axon 1294

 

Qty1: 10 mg / €115  $150 

 

Qty2: 50 mg / €465  $605 

 

Qty3: on request

 

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Blocker of the slow delayed rectifier K+ current via KCNQ1 channels

 

References: online ref 1

 

C Lengyel et al. Pharmacological block of the slow component of the outward delayed rectifier current (I(Ks)) fails to lengthen rabbit ventricular muscle QT(c) and action potential duration. Br. J. Pharmacol. 2001, 132, 101-110.

 

G Seebohm et al. A kinetic study on the stereospecific inhibition of KCNQ1 and I(Ks) by the chromanol 293B. Br. J. Pharmacol. 2001, 134, 1647-1654.

 

 

 

 

Chemical name: trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide

 

Chromanol 293B | K channel blocker | Axon Medchem | Axon 1294

axonmedchem.com © 2012

 

Axon Ligands In The Field:

 

Chromanol 293B | K chan. blocker

DMP 543 | K channel blocker

HMR 1098 | KATP chan. blocker

Kv1.3 blocker 42 | Axon 1735

PNU 37883 | KATP chan. blocker

S9947 | IKur channel blocker

XE 991 | KCNQ channel blocker

 

BMS 204352 | K channel opener

1-EBIO | KCa channel opener

NN 414 | KATP channel opener

Retigabine | KCNQ chan. opener

 

 

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