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FK866

K 22.175

CAS658084-64-1

C₂₄H₂₉N₃O₂  MW 391.506

Purity: 99%

Ordering Information:

Cat. No.: Axon 1279      Prime Source   

Qty1:  5 mg / €115  $150

Qty2: 10 mg / €165  $215

Qty3: 50 mg / €660  $858

Qty4: on request

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Biological Activity:   Highly specific inhibitor of nicotinamide phosphoribosyltransferase (NAMPT); NAD biosysthesis inhibitor; Tumor cell apoptosis agent   Note: Water-soluble FK 866 hydrochloride (Axon 1546) is available, which is ideal for in vivo experiments.   References: online1, 2, 3   M. Hasmann and I. Schemainda, FK866, a highly specific noncompetitive inhibitor of nicotinamide phosphoribosyltransferase, represents a novel mechanism for induction of tumor cell apoptosis, Cancer Res. 2003, 63, 7436-7442.   A Pogrebniak et al. Chemopotentiating effects of a novel NAD biosynthesis inhibitor, FK866, in combination with antineoplastic agents. Eur. J. Med. Res. 2006, 11(8), 313-321.   K Holen et al. The pharmacokinetics, toxicities, and biologic effects of FK866, a nicotinamide adenine dinucleotide biosynthesis inhibitor. Invest. New Drugs. 2008, 26(1), 45-51. [online abstract]    Chemical name: (E)-N-[4-[1-(benzoyl)piperidin-4-yl]butyl]-3-pyridin-3-ylprop-2-enamide

FK866 | NAMPT inhibitor | Axon Medchem | Axon 1279 | FK-866 - K22.175 - K 22.175

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