Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

PB28 dihydrochloride

CAS 172907-03-8 (HCl)

172906-90-0 (free base)

C24H40Cl2N2O  MW 442.49

Purity: 99%

Ordering Information:

Cat. No. Axon 1272

Qty1: 10 mg / €76  $99

Qty2: 50 mg / €306  $398

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Contact us for payment and tech support.

Biological Activity:   High affinity sigma-2 agonist.   References: online 1   G Cassano et al. The sigma-2 receptor agonist PB28 inhibits calcium release from the endoplasmic reticulum of SK-N-SH neuroblastoma cells. Cell Calcium 2006, 40(1), 23-28. doi:10.1016/j.ceca.2006.03.004. PMID 16687172.   A Azzariti et al. Cyclohexylpiperazine derivative PB28, a sigma2 agonist and sigma1 antagonist receptor, inhibits cell growth, modulates P-glycoprotein, and synergizes with anthracyclines in breast cancer. Mol. Cancer Ther. 2006, 5(7), 1807-1816. doi:10.1158/1535-7163.MCT-05-0402. PMID 16891467.     Chemical Name: 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl)-propyl]-piperazine dihydrochloride

PB 28 | Sigma-2 agonist | Axon Medchem | Axon 1272 | PB28

axonmedchem.com © 2012

Axon Ligands In The Field:

PB 28 | Sigma-2 agonist

BD-1047 | Sigma-1 antagonist

Axon Ligands^TM

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.