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4-Methylhistamine dihydrochloride

CAS 36376-47-3 (HCl)

36507-31-0 (free base)

C6H11N3.2HCl 

MW 197.05

Purity: >98%

Ordering Information:

Cat. No. Axon 1261

Qty1: 10 mg / €115  $150

Qty2: 50 mg / €465  $605

Qty3: on request

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Biological Activity:   Potent and selective histamine H4 agonist.   References: online 1, 2   RK Morgan et al. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J. Immunol. 2007, 178(12), 8081-9.   D Dijkstra et al. Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. J Allergy Clin Immunol. 2007, 120(2), 300-7.   Lim et al. Evaluation of histamine H1- H2-, and H3-receptor ligands at the human histamine H4 receptor: identification of 4-methylhistamine as the first potent and selective H4 receptor agonist. J. Pharmacol. Exp. Ther. 2005, 314, 1310.     Chemical Name: 2-(5-Methyl-3H-imidazol-4-yl)-ethylamine dihydrochloride

4-Methylhistamine | H4 agonist | Axon Medchem | Axon 1261

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