Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

Desmethyl-YM-298198

CAS 299901-57-8

C17H20N4OS.HCl  MW 364.89

Purity: 98%

Ordering Information:

Cat. No. Axon 1259

Qty1: 10 mg / €105  $137

Qty2: 50 mg / €405  $527

Qty3: on request

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Biological Activity:   Derivative of YM-298198 (Axon 1260), a selective and noncompetitive mGluR1 antagonist.   References: online 1   Koharaet al. Radioligand binding properties and pharmacological characterization of 6-Amino-N-cyclohexyl-N,3-dimethyl-thiazolo[3,2-a]-benzimidazole-2-carboxamide (YM-298198), a high-affinity, selective and noncompetitive antagonist of metabotropic glutamate receptor type 1. J. Pharmacol. Exp. Ther. 2005, 315, 163.               Chemical Name: 6-Amino-3-methyl-benzo[4,5]imidazo[2,1-b]thiazole-2-carboxylic acid cyclohexylamide hydrochloride

Desmethyl YM 298198 | mGluR1 antagonist | Axon Medchem | Axon 1259 - Desmethyl YM298198

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Axon Ligands in the field:

MPEP | mGluR5 antagonist

Fenobam | mGluR5 antagonist

YM 298198 | mGlu1 antagonist

LY 367385 | mGlu1a antagonist

CP 101606 | NMDA antagonist

Ifenprodil | NMDA antagonist

Eliprodil | NMDA antagonist

N20C | NMDA antagonist

Gavestinel | Glycine antagonist

Ro 25-6981 | NMDA antagonist

CNQX | AMPA/kanaite antagonist

DNQX | AMPA/kainate antagonist

GYKI 53655 | AMPA antagonist

YM-90K | AMPA antagonist

Axon Ligands ^TM

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.