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Necrostatin-1

CAS 4311-88-0

C13H13N3OS  MW 259.33

Purity: 99%

Ordering Information:

Cat. No.: Axon 1258       

Qty1: 25 mg / €95  $124

Qty3: 100 mg / €285  $371

Qty4: on request

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Biological Activity:   A cell-permeable, potent, and selective inhibitor of necroptosis; Acts as a selective and ATP-competitive inhibitor of RIP1 kinase with negligible effect of RIP2 kinase activity.   References:   A. Degterev et al. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nature Chem. Biol. 2008, 4, 313-321. [online]   A. Degterev et al. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nature Chem. Biol. 2005, 1, 112. [online]   Chemical name: 5-(1H-Indol-3-ylmethyl)-3-methyl-2-thioxo-4-imidazolidinone

Necrostatin-1 | Necroptosis inhibitor | Axon Medchem | Axon 1258

Axon Ligands^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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