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SR 49059 - Relcovaptan

CAS 150375-75-0

C28H27Cl2N3O7S  MW 620.50

Purity: 99% (optically pure)

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1256      Prime Source

Qty1: 5 mg / €125  $163

Promotion: 2 x 5 mg  @  €180  $234

Qty2: 25 mg / €435  $566

Promotion: 2 x 25 mg  @  €660  $858

Qty3: on request

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Biological Activity:   Highly potent and selective vasopressin V1a receptor antagonist   References: online ref 1   Steinwall et al. The effect of relcovaptan (SR 49059), an orally active vasopressin V1a receptor antagonist, on uterine contractions in preterm labor. Gynecol Endocrinol. 2005 20(2), 104-9.   Tahtaoui et al. Identification of the binding sites of the SR 49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors. J. Biol. Chem. 2003, 278, 40010.     Chemical Name: (S)-1-[(2R,3S)-5-Chloro-3-(2-chloro-phenyl)-1-(3,4-dimethoxy-benzenesulfonyl)-3-hydroxy-2,3-dihydro-1H-indole-2-carbonyl]-pyrrolidine-2-carboxylic acid amide

SR 49059 | Vasopressin V1a antagonist | Axon Medchem | Axon 1256 | SR49059 | Relcovaptan

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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