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SR 142948

CAS 184162-64-9

C₃₉H₅₁N₅O₆  MW 685.86 

Purity: 98 %

Ordering Information:

Cat. No. Axon 1255        Prime Source

Qty1: 5 mg / €135  $176

Promotion: 2 x 5 mg @ €200  $260

Qty2: 25 mg / €435  $566

Promotion: 2 x 25 mg @ €680  $884

Qty3: on request

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Biological Activity:   Neurotensin (NT) receptor antagonist; orally active in vivo.   References: online 1, 2   Gully et al. Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J. Pharmacol. Exp. Ther. 1997, 280, 802.   SM Reynolds et al. Neurotensin antagonist acutely and robustly attenuates locomotion that accompanies stimulation of a neurotensin-containing pathway from rostrobasal forebrain to the ventral tegmental area. Eur. J. Neurosci. 2006, 24(1), 188–96.     Chemical Name: 2-([5-(2,6-dimethoxyphenyl)-1-[4-[3-(dimethylamino)propyl-methylcarbamoyl]-2-propan-2-ylphenyl]pyrazole-3-carbonylamino)adamantane-2-carboxylic acid

SR 142948 | NT antagonist | Axon Medchem | Axon 1255 | SR142948

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Axon Ligands In The Field:

SR 48692 | NT antagonist

SR 142948 | NT antagonist

Axon Ligands ^TM

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.