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Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

 

 

 

  

LE135

LE-135

CAS 155877-83-1

C29H30N2O2  MW 438.57

Purity: 98%

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1242    Prime Source

 

Qty1: 10 mg / €95  $124

 

Qty2: 50 mg / €380  $494

 

Qty3: on request

 

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

 

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Biological Activity:

 

retinoid antagonist, beta type selective

 

References: online 1

 

Li et al Identification of a novel class of retinoic acid receptor β-selective retinoid antagonists and their inhibitory effects on AP-1 activity and retinoic acid-induced apoptosis in human breast cancer cells. J. Biol. Chem.1999, 274. 15360.

 

 

 

Chemical Name: 4-(5,7,7,10,10-Pentamethyl-7,8,9,10-tetrahydro-5H-5,12-diaza-benzo[4,5]cyclohepta[1,2-b]naphthalen-13-yl)-benzoic acid

 

LE 135 | RAR antagonist | Axon Medchem | Axon 1242 - LE135

axonmedchem.com © 2012

 

Axon Ligands In The Field:

Nuclear Receptors - Retinoid Acid Receptor (RAR) (click)

 

BMS 189961 | RAR agonist

BMS 270394 | RAR agonist

CH 55 | RAR agonist

LE 135 | RAR antagonist