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Biological Activity:
Inhibitor of activated Akt. Anticancer, chemopreventive agent
References: online 1, 2
AS Nair et al. Deguelin, an Akt Inhibitor, Suppresses IKBa Kinase Activation Leading to Suppression of NF-KB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion. J. Immunol. 2006, 177, 5612-5622.
KH Chun et al. Effects of deguelin on the phosphatidylinositol 3-kinase/Akt pathway and apoptosis in premalignant human bronchial epithelial cells. J. Natl. Cancer Inst. 2003, 95, 291-302.
Chemical Name: (7aS,13aS)-9,10-Dimethoxy-3,3-dimethyl-13,13a-dihydro-3H,7aH-pyrano[2,3-c;6,5-f']dichromen-7-one
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