|
Biological Activity:
PDE4 inhibitor, more active R-enantiomer of Rolipram (Axon 1212) in comparison with (S)-(+)-Rolipram (Axon 1432).
* Rolipram is an anti-inflammatory drug; also with rich CNS profile, such as antidepressive, antipsychotic effects and/or neuroprotection.
References:
HH Schneider et al. Stereospecific binding of the antidepressant rolipram to brain protein structures. Eur J Pharmacol. 1986, 127(1-2), 105-15. [online]
DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.
SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46. PMID 17081698
RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Letters. 2007, 418(2). 165–9.
Chemical Name: (R)-4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
| 
