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PD 98059

NSC 679828

CAS 167869-21-8

C16H13NO3  MW 267.29

Purity: 99%

Soluble in DMSO

Ordering Information:

Cat. No. Axon 1223

Qty1: 10 mg / €85  $111

Promotion: 2 x 10 mg @ €120  $156

Qty2: 50 mg / €255  $332

Promotion: 2 x 50 mg @ €380  $494

Qty3: on request

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Biological Activity:   Potent and cell-permeable inhibitor of mitrogen-activated protein (MAP) kinase kinase (also known as MAPK/ERK kinase or MEK).   References:   DR Alessi et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem. 1995, 270(46), 27489-94.   FJ Dumont et al. Inhibition of T cell activation by pharmacologic disruption of the MEK1/ERK MAP kinase or calcineurin signaling pathways results in differential modulation of cytokine production. J. Immunol. 1998, 160(6), 2579-89.     Chemical Name: 2-(2-Amino-3-methoxy-phenyl)-chromen-4-one

PD 98059 | MEK inhibitor | Axon Medchem | Axon 1223 | PD98059

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

Axon Ligands In This Field: