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Rolipram

CAS 61413-54-5

C16H21NO3  MW 275.34

Purity: >98%

Ordering Information:

Cat. No. Axon 1212

Qty1: 10 mg / €75  $98

Qty2: 50 mg / €275  $358

Qty3: on request

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Biological Activity:   PDE4 inhibitor, as an anti-inflammatory drug; also with rich CNS profile, such as antidepressive, antipsychotic effects and/or neuroprotection.   References: online 1, 2   DE Griswold et al. Effect of selective phosphodiesterase type IV inhibitor, rolipram, on fluid and cellular phases of inflammatory response. Inflammation. 1993, 17(3), 333–44.   SJ Kanes et al. Rolipram: A specific phosphodiesterase 4 inhibitor with potential antipsychotic activity. Neuroscience. 2006, 144, 239-46. PMID 17081698   RW Chen et al. Broad spectrum neuroprotection profile of phosphodiesterase inhibitors as related to modulation of cell-cycle elements and caspase-3 activation. Neuroscience Lett. 2007, 418(2), 165–9.     Chemical Name: 4-(3-Cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one

Rolipram | PDE4 inhibitor | Axon Medchem | Axon 1212 | SB 95952 - ZK 62711

Axon Ligands TM  - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.