Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

U 50488 hydrochloride

.HCl

CAS 67198-13-4 (free base)

C₁₉H₂₆Cl₂N₂O.HCl  MW 405.79

Purity: 99 %

Ordering Information:

Cat. No. Axon 1202

Qty1: 10 mg / €65  $85

Qty2: 50 mg / €195  $254

Qty3: on request

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Biological Activity:   Selective nonpeptide kappa-opiod receptor agonist, which has been found to stimulate the release of adrenocorticotropin (acth) via the release of hypothalmic arginine vasopressin and corticitropin releasing factor.   References:   ML Laorden et al. Effects of U-50,488H and U-50,488H withdrawal on c-fos expression in the rat paraventricular nucleus. Correlation with c-fos in brainstem catecholaminergic neurons. Br. J. Pharmacol. 2003, 138, 1544–1552.     Chemical Name: 2-(3,4-Dichloro-phenyl)-N-methyl-N-(trans-2-pyrrolidin-1-yl-cyclohexyl)-acetamide

U 50488 | kappa opioid agonist | Axon Medchem | Axon 1202 | U50488

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Axon Opioid Receptor Ligands:

nor-BNI | k opioid antagonist

β-FNA | μ opioid antagonist

GNTI | k opioid antagonist

Nalmefene | opioid antagonist

Naloxonazine | opioid antagonist

Naloxone Benzoylhydrazone

BAN ORL 24 | NOP antagonist

JTC 801 | NOP antagonist

SB 612111 | NOP antagonist