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L-838,417  - L 838417

CAS 286456-42-6

 C19H19F2N7O  MW 399.47

Purity: 99%

Ordering Information:

Cat. No. Axon 1196       Prime Source

Qty1:  5 mg (research sample) / €95  $124

Promotion: 2 x 5 mg @ €152  $198

Qty2: 25 mg (research sample) / €350  $455

Promotion: 2 x 25 mg @ €560  $728

Qty3: on request

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Biological Activity:   Partial agonist at non-a1 GABAA and antagonist at GABAA-a1 receptor   References: online ref 1, 2, 3   J Knabl etal. Reversal of pathological pain through specific spinal GABAA receptor subtypes. Nature 2008, 451, 330-334. [online]   NR Mirza et al. Comparative cue generalisation profiles of L-838,417, SL651498, zolpidem, CL218,872, ocinaplon, bretazenil, zopiclone and various benzodiazepines in chlordiazepoxide and zolpidem drug discrimination. J. Pharmacol. Exp. Ther. 2006, 316(3), 1291-1299. [abstract]     Chemical Name: 7-tert-Butyl-3-(2,5-difluoro-phenyl)-6-(2-methyl-2H-[1,2,4]triazol-3-ylmethoxy)-[1,2,4]triazolo[4,3-b]pyridazine

L-838,417 | GABAA Ligand | Axon Medchem | Axon 1196 | L838417

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research and synthesis.

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