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BMS 270394

(R)-(+)-BMS 270394

CAS262433-54-5

C23H26FNO4  MW 399.47

Purity: 99% (optically pure)

Ordering Information:

Cat. No. Axon 1173    Prime Source

Qty1: 5 mg (research sample) / €165  $215

Qty2: 25 mg (research sample) / €660  $858

Qty3: on request

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Biological Activity:   Nuclear retinoic acid receptor (RAR) gamma agonist; more active enantiomer of BMS 189961 (Axon 1194)   References: online ref 1, 2   B P Klaholz et al. Enantiomer Discrimination Illustrated by High-Resolution Crystal Structures of the Human Nuclear Receptor hRARγ. Proc. Natl. Acad. Sci. USA. 2000, 97(12), 6322–6327.   R Chidambaram et al. A Practical Synthesis of the RAR Agonist, BMS-270394. Org. Proc. Res. Dev. 2002, 6(5), 632 -636.     Chemical Name: 3-Fluoro-4-[(R)-2-hydroxy-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-acetylamino]-benzoic acid

BMS 270394 | RAR agonist | Axon Medchem | Axon 1173 | R-(+) BMS270394

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Axon Ligands In The Field:

Nuclear Receptors - Retinoid Acid Receptor (RAR) (click)

BMS 189961 | RAR agonist

BMS 270394 | RAR agonist

CH 55 | RAR agonist

LE 135 | RAR antagonist