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Biological Activity:
NMDA antagonist; selectively blocks NMDA receptors containing the NR2B subunit; neuroprotective agent.
References: online 1
Kurihara, et al. Selective dysfunction of the vagal component of the baroflex following cerbral ischemia: protection by ifenprodil and flunarzine. Eur. J. Pharmacol. 1990, 190, 23.
Carter, et al. Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor. Eur. J. Pharmacol. 1989, 164, 611.
Chemical Name: 4-[(1R*,2S*)-2-(4-Benzyl-piperidin-1-yl)-1-hydroxy-propyl]-phenol (* relative stereochemistry)
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