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Ro 28-0450

(±)-Ro 28-1675

CAS 300352-96-9

C18H22N2O3S2  MW 378.52

Purity: >98%

Ordering Information:

Cat. No. Axon 1134

Qty1: 10 mg (research sample) / €115  $150

Qty2: 50 mg (research sample) / inquire

Qty3: on request contract research synthesis

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Biological Activity:   Glucokinase GK activator; its more active (R)-enantiomer is Ro-28-1675 (Axon 1356).   References: online 1, 2   Grimsby et al. Allosteric Activators of Glucokinase: Potential Role in Diabetes Therapy. Science Signaling 18 July 2003: 370.   T Kietzmann and GK Ganjam. Glucokinase: old enzyme, new target. Expert Opinion on Therapeutic Patents. 2005, 15(6), 705-713.         Chemical Name: 3-Cyclopentyl-2-(4-methanesulfonyl-phenyl)-N-thiazol-2-yl-propionamide

RO 28-0450 | Glucokinase activator | Axon Medchem | Axon 1134 | RO280450 - (±) Ro 28-1675

Axon Ligands TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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In the Spotlight

Ro 28-0450 was found as highly effective GK activator in 2001. Later Roche identified its R-enantiomer (Ro 28-1675) as more active. Recent R&D highlighted on the following small molecule glucokinase activators: e.g.

Ro 28-1675

GKA1

GKA2

Thiophene22

Banyu compound

LY 2121260

PSN-105

and some "UREAs"

.... 

Click To See Signal Transduction Modulators At Axon Collection