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GW 843682X

CAS 660868-91-7

C22H18F3N3O4S  MW 477.46

Purity: >98%

Soluble in DMSO up to 100 mM

Ordering Information:

Cat. No. Axon 1131

Qty1:  5 mg / €95  $124

Qty2: 10 mg / €145  $189

Qty3: 25 mg / €295  $384

Qty4: on request

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Biological Activity:   Polo-like kinase (PLK) inhibitor; selective at PLK1 (IC50: 2 nM) and PLK3 (IC50: 9 nM).   References: online 1, 2   EF Johnson et al. Pharmacological and Functional Comparison of the Polo-like Kinase Family: Insight into Inhibitor and Substrate Specificity. Biochemistry 2007, 46(33), 9558.   T Lansing et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol. Cancer Ther. 2007, 6, 450-459.     Chemical Name: 5-(5,6-Dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(trifluoro methyl)phenyl]methoxy]-2-thiophenecarboxamide

GW 843682X | PLK 1/3 inhibitor | Axon Medchem | Axon 1131 | GW843682X - GW 843682 X

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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