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BI 2536

CAS 755038-02-9

C28H39N7O3  MW 521.66

Purity: 99% (optically pure)

Soluble in DMSO to 10 mM

Ordering Information:

Cat. No. Axon 1129    Prime Source

Qty1: 2 mg (research sample) / €99  $129

Qty2: 5 mg (research sample) / €145  $189

Promotion: 2 x 5 mg @ €220  $286

Qty3: 25 mg (research sample) / €505  $657

Qty4: on request

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Biological Activity:   Potent and selective polo-like kinase (PLK) 1 inhibitor     References:   M Steegmaier et al. BI 2536, a Potent and Selective Inhibitor of Polo-like Kinase 1, Inhibits Tumor Growth In Vivo. Curr Biol 2007, 17, 316-322. [online]   P Lénárt et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol 2007, 17(4), 304-15. [online]   M Sebastian et al. The Efficacy and Safety of BI 2536, a Novel Plk-1 Inhibitor, in Patients with Stage IIIB/IV Non-small Cell Lung Cancer Who Had Relapsed after, or Failed, Chemotherapy: Results from an Open-Label, Randomized Phase II Clinical Trial. J. Thor. Oncol. 2010, 5(7), 1060-1067. [online]   HJ Stewart et al. The polo-like kinase inhibitor BI 2536 exhibits potent activity against malignant plasma cells and represents a novel therapy in multiple myeloma. Exp. Hematol. 2011, 39(3), 330-338. [online]     Chemical Name: (R)-4-[(8-Cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-6-oxo-2-pteridinyl)amino]-3-methoxy-N-(1-methyl-4-piperidinyl)benzamide

BI 2536 | PLK-1 inhibitor | Axon Medchem | Axon 1129 | BI2536

Axon Ligands ^TM - Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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