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Biological Activity:
Active metabolite of MDL 100907 (Axon 1104), a selective 5-HT2A antagonist; Precursor for [11C]MDL100907.
References: online 1, 2
DO Scott and TG Heath. Investigation of the CNS penetration of a potent 5-HT2A receptor antagonist (MDL 100,907) and an active metabolite (MDL 105,725) using in vivo microdialysis sampling in the rat. J. Pharm. Biomed Anal. 1998, 17(1), 17-25.
T Ullrich et al. A practical synthesis of the serotonin 5-HT2a receptor antagonist MDL100907, its enantiomers and their 3-phenolic derivatives as precursors for [11C]labelled PET ligands. Bioorg. Med. Chem. 2000, 8, 2427-2432.
Y Huang et al. An efficient synthesis of the precursors of [11C]MDL100907 labeled in two specific positions. J. Labelled Compd. Radiopharm. 1999, 42, 949-957.
JH Kehne et al. Effects of the Selective 5-HT2A Receptor Antagonist MDL 100,907 on MDMA-Induced Locomotor Stimulation in Rats. Neuropsychopharmacology 1996, 15, 116-124.
Chemical Name: 3-((R)-{1-[2-(4-Fluoro-phenyl)-ethyl]-piperidin-4-yl}-hydroxy-methyl)-2-methoxy-phenol
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