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Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

 

 

 

  

S 14506 hydrochloride

CAS 135721-98-1 (HCl),

135722-25-7 (parent)

C24H26FN3O2.HCl  MW 443.94

Purity: >98%

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1088

 

Qty1: 5 mg / €85  $111

Qty2: 10 mg / €135  $176

Qty3: 50 mg / inquire

 

Qty4: on request

 

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

 

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Biological Activity:

 

Very potent and selective 5-HT1A agonist

 

References:

 

G Milligan et al. S 14506: novel receptor coupling at 5-HT1A receptors. Neuropharmacology. 2001, 40, 334. [online]

 

AJ Goudie. Assessment of the dependence potential of the potent high-efficacy 5-HT1A agonist S-14506 in rats. J Psychopharmacol. 1994, 8(4), 213-221. [online]

 

FC Colpaert et al. S 14506: A novel, potent, high-efficacy 5-HT1A agonist and potential anxiolytic agent. Drug Develop. Res. 1992, 26(1), 21–48. [online]

 

 

 

 

Chemical Name: 4-Fluoro-N-[2-[4-(7-methoxy-1-naphthalenyl)-1-piperazinyl] ethyl]benzamide hydrochloride

 

S 14506 | 5-HT1A agonist | Axon Medchem | Axon 1088 | S14506

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Axon 5-HT1A Ligands: e.g.

8-OH-DPAT | 5-HT1A agonist

(+)-8-OH-DPAT | 5-HT1A agonist

(-)-NPPCC | 5-HT1A agonist

S 14506 | 5-HT1A agonist

Desmethyl S14506

U 92016A | 5-HT1A agonist

LY 426965 | 5-HT1A antagonist

p-MPPF | 5-HT1A antagonist

p-MPPI | 5-HT1A antagonist

WAY 100135 | 5-HT1A antagonist

(S)-WAY100135 | 5-HT1A antag.

WAY 100635 | 5-HT1A antagonist

DWAY | 5-HT1A antagonist

FWAY | 5-HT1A antagonist

 

Axon 5-HT1B/1D Ligands: e.g.

CGS 12066B | 5-HT1B agonist 

Sumatriptan | 5-HT1B/1D agonist

GR 127935 | 5-HT1B/1D antagonist

GMC 2-29 | 5-HT1B/1D antagonist

GMC 3-15 | 5-HT1B/1D antagonist

GMC 15-27 | 5-HT1B/1D antag.

SB 216641 | 5-HT1B antagonist

LY 393558 | SRI, 5-HT1B/1D antag

 

Axon 5-HT1F Ligands:

LY 334370 | 5-HT1F agonist