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GR 127935

CAS 148672-13-3

C29H31N5O3  MW 497.6

Purity: >98%

Ordering Information:

Cat. No. Axon 1079   discountinued

Note: the water-soluble salt form, GR 127935 hydrochloride (Axon 1813) is available.

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Biological Activity:   Putative and selective 5-HT1B/1D antagonist   Note: the water-soluble GR 127935 hydrochloride (Axon 1813) is available.   References: online 1   PJ Pauwels. Pharmacological Properties of a Putative 5-HT1B/D Receptor Antagonist GR 127,935. CNS Drug Reviews 1996, 2(4), 415–428.   JW Clitherow et al. Evolution of a novel series of [(N,N-dimethylamino)propyl]- and piperazinylbenzalides as the first selective 5-HT1D antagonists. J. Med. Chem. 1994, 37, 2253. [online]   Y Liao et al. New selective and potent 5-HT1B/1D or 5-HT1B antagonists: chemistry and pharmacological evaluation of GR127935-like compounds. J. Med. Chem. 2000, 43, 517-525. [online]     Chemical Name: 2'-Methyl-4'-(5-methyl-[1,2,4]oxadiazol-3-yl)-biphenyl-4-carboxylic acid [4-methoxy-3-(4-methyl-piperazin-1-yl)-phenyl]-amide

GR 127935 | 5-HT1B/1D antagonist | Axon Medchem | Axon 1079 | GR127935

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Axon 5-HT1B/1D Ligands:

Axon 5-HT1A Ligands: e.g.