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(-)-PD 128907 hydrochloride

 

 

CAS112960-16-4

C14H19NO3·HCl 

MW 285.77

Purity: >98%, >98% ee

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1074

 

Qty1: 5 mg / €135  $176

 

Qty2: 25 mg / €475  $618

 

Qty3: on request

 

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Biological Activity:

 

PD 128907 is a selective D3 dopamine receptor agonist; (-)-enantiomer is less active in comparison with (+)-enantiomer (Axon 1073).

 

References: online ref 1, 2

 

Pugsley et al. Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907. J. Pharmacol. Exp. Ther. 1995, 275 1355.

 

Witkin et al. Atypical antipsychotic-like effects of the dopamine D3 receptor agonist (+)-PD 128907. Eur. J. Pharmacol. 1998, 347, R1.

 

Chemical Name: (-)-(4aS,10bS)-3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-[1]benzopyrano[4,3-b]-1,4-oxazin-9-ol hydrochloride; also as trans-(-)-PD128907 hydrochloride

 

(-)-PD 128907 | D3 agonist | Axon Medchem | Axon 1074

axonmedchem.com © 2011

 

DRD3 related ligands: e.g.

 

7-hydroxy-DPAT | D3 agonist

(R)-(+)-7-OH-DPAT | D3 agonist

(±)-PD 128907 | D3 agonist

(+)-PD 128907 | D3 agonist

ST 198 | D3 antagonist

U 99194 | D3 antagonist

GR 103691 | D3 antagonist

 

 

 

Axon Ligands (TM) - alphabetic: [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]