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Biological Activity:
Very potent and selective D2 agonist, more active enantiomer
Note: Appropriate chiral precursor(s) for making D2 radiotracer, [11C]-(+)-PHNO, can be provided upon request.
References: online ref 1
Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.
N Ginovart et al. Binding characteristics and sensitivity to endogenous dopamine of [11C]-(+)-PHNO, a new agonist radiotracer for imaging the high-affinity state of D2 receptors in vivo using positron emission tomography. J. Neurochem. 2006, 97(4), 1089-1103(15). [abstract]
P Seeman et al. Dopamine receptors labelled by PHNO. Synapse. 1993, 14(4), 254-62. [abstract]
A Graff-Guerrero et al. The effect of antipsychotics on the high-affinity state of D2 and D3 receptors: a positron emission tomography study With [11C]-(+)-PHNO. Arch Gen Psychiatry. 2009, 66(6), 606-15. [abstract]
Chemical Name: (4aR, 10bR)-(+)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-Naphth[1,2-b]-1,4-oxazin-9-ol
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