Chemistry Service Platform - CRO in Medicinal Chemistry

 

 

 

  

(+/-)-PHNO hydrochloride

CAS 100935-99-7

C15H21NO2.HCl 

MW 283.798

Purity: >98%

 

 

 

 

Ordering Information:

 

Cat. No. Axon 1070

 

Qty1: 5 mg (research sample)

 

Qty2: 25 mg (research sample)

 

Qty3: on request

 

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Biological Activity:

 

Potent and selective D2 agonist, racemate of PHNO, its more active enantiomer is (+)-PHNO (Axon 1071)

 

References: online ref 1

 

Martin et al. Selectivity of (+)-4-propyl-9-hydroxynaphthoxazine [(+)-PHNO] for dopamine receptors in vitro and in vivo. J. Pharmacol. Exp. Ther. 1985, 233, 2, 395-401.
 

 

 

Chemical Name: trans-(+/-)-(4aR, 10bR)-4-Propyl-3,4,4a,5,6,10b-hexahydro-2H-Naphth[1,2-b]-1,4-oxazin-9-ol

 

(+/-)-PHNO | D2 agonist | Axon Medchem | Axon 1071 | rac-PHNO

 

Axon Ligands TM - alphabetic:  [A] [B] [C] [D] [E] [F] [G] [H] [I] [J] [K] [L] [M] [N] [O] [P] [Q] [R] [S] [T] [U] [V] [W] [X] [Y] [Z]

 

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.

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Axon Dopamine Ligands: e.g.

 

S-(+)-Dinapsoline | D1 Agonist

GR 103691 | D3 antagonist

5-hydroxy-DPAT | D2 agonist

(S) 5-hydroxy-DPAT | D2 agonist

7-hydroxy-DPAT | D3 agonist

(R)-(+)-7-OH-DPAT | D3 agonist

Molindone | D2 antagonist

N-0426 | DA agonist

N 0734 | DA agonist  

NNC 776 | D1 antagonist

R(-)-NPA | D2 agonist

Norapomorphine | DA agonist

Rotigotine - N-0437 | DA agonist

(-)-Rotigotine | DA agonist

RU 24213 | D2 agonist

(±)-PD 128907 | D3 agonist

(+)-PD 128907 | D3 agonist

(+)-PHNO | D2 agonist

Piribedil | Dopamine agonist

PPHT - N-0434 | D2 agonist

SKF-83566 | D1 antagonist

ST 148 | D2 antagonist

ST 198 | D3 antagonist

TL 99 | Dopamine agonist

TL 102 | Dopamine agonist

TL 232 | Dopamine agonist

U 99194 | D3 antagonist