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(S)-(-)-8-Hydroxy-DPAT hydrobromide

S-(-)-8-OH-DPAT

CAS 78095-20-2 (HBr)

80300-10-3 (free base)

C₁₆H₂₅NO.HBr MW 328.29 

Purity: 99%, >98%ee

Ordering Information:

Cat. No. Axon 1017       Prime Source

Qty1: 10 mg / €115  $150

Qty2: 50 mg / €460  $598

Qty3: on request

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Biological Activity:   5-HT1A receptor partial agonist, less active enantiomer of (±)-8-OH-DPAT (Axon 1015), in comparison with R-(+)-8-hydroxy-DPAT (Axon 1016) as a full 5-HT1A agonist.   References: online ref 1, 2   Yoshitake and Kehr (2004) Differential effects of (R)-, (R, S)- and (S)-8-hydroxy-2-(di-n-propylamino)tetralin on hippocampal serotonin release and induction of hypothermia in awake rats. Life Sci. 74 2865. Cornfield, et al. Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. Mol. Pharmacol. 39, 780, (1991)         Chemical Name: (S)-(-)-2-Dipropylamino-8-hydroxy-1,2,3,4-tetrahydro naphthalene hydrobromide or (S)-(-)-8-Hydroxy-2-(di-n-propylamino)tetralin hydrobromide

S-(-)-8-Hydroxy-DPAT | 5-HT1A agonist | Axon Medchem | S (-) 8-OH-DPAT | Axon 1017

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Axon 5-HT1A Ligands: e.g.

p-MPPF

p-MPPI

(-)-NPPCC

S 14506

WAY 100135

WAY 100635

(+/-)-LY 426965

S(+)-426965

Desmethyl S 14506

DWAY 100165

FCWAY

8-OH-DPAT

R(+)-8-OH-DPAT

U 92016A

Axon Ligands ^TM

Research chemicals for biological study. Some high-profile samples could be provided under terms of contract research synthesis.