(S) 5-hydroxy-DPAT | D2 agonist | Axon Ligands | Axon Medchem

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(S)-5-Hydroxyl-DPAT hydrobromide

S-5-OH-DPAT

CAS 182210-74-8 (HBr)

68643-08-3 (free base)

C16H25NO.HBr MW 328.29

Purity: >98%, >98%ee

Ordering Information:

Cat. No. Axon 1008

Qty1: 5 mg / 145 $189

Qty2: 25 mg / inquire

Qty3: on request

Send enquiry to: order@axonmedchem.com

or by fax to: +31-50-3600390.

Biological Activity:

Potent and selective dopamine (DA) D₂-receptor agonist; more active (S)- enantiomer of 5-OH-DPAT (Axon 1006); its opposite enantiomer, R-5-OH-DPAT (Axon 1007), is a weakly potent D2 antagonist.

References:online 1

A Karlsson et al. (R)- and (S)-5-hydroxy-2-(dipropylamino)tetralin (5-OH DPAT): Assessment of optical purities and dopaminergic activities. Chirality. 1989-1995, 2(2), 90-95.

B Shi et al. Radiosynthesis and in vitro evaluation of 2-(N-alkyl-N-1'-11C-propyl)amino-5-hydroxytetralin analogs as high affinity agonists for dopamine D-2 receptors.Nucl Med Biol. 1999, 26(7), 725-35. (PubMed)

J Mukherjee et al. In vitro and in vivo evaluation of the binding of the dopamine D2 receptor agonist (11)C-(R,S)-5-hydroxy-2-(di-n-propylamino)tetralin in rodents and nonhuman primate.Synapse. 2000, 37(1), 64-70. (PubMed)

Chemical Name: (S)-6-Dipropylamino-5,6,7,8-tetrahydro-naphthalen-1-ol hydrobromide

(S) 5-hydroxy-DPAT | D2 agonist | Axon Medchem | Axon 1008 | S-5-OH-DPAT

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